Sphingolipids in mitochondria-from function to disease

Maryam Jamil; Lauren Ashley Cowart

doi:10.3389/fcell.2023.1302472

Sphingolipids in mitochondria-from function to disease

Front Cell Dev Biol. 2023 Nov 21:11:1302472. doi: 10.3389/fcell.2023.1302472. eCollection 2023.

Authors

Maryam Jamil^{1

2}, Lauren Ashley Cowart^{2

3}

Affiliations

¹ Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA, United States.
² Department of Biochemistry and Molecular Biology, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA, United States.
³ Richmond Veteran's Affairs Medical Center, Richmond, VA, United States.

Abstract

Sphingolipids are not only structural components of cellular membranes but also play vital roles in cell signaling and modulation of cellular processes. Within mitochondria, sphingolipids exert diverse effects on mitochondrial dynamics, energy metabolism, oxidative stress, and cell death pathways. In this review, we summarize literature addressing the crucial role of sphingolipids in mitochondria, highlighting their impact on mitochondrial dynamics, cellular bioenergetics, and important cell processes including apoptosis and mitophagy.

Keywords: NAFLD; S1P; cancer; ceramide; mitochondria; sphingolipids.

Publication types

Review

Abstract

Publication types

Grants and funding