Association between Hepatitis B virus and gastric cancer: A systematic review and meta-analysis

Rong Yu; Jingru Huang; Hewei Peng; Shuo Yin; Weijiang Xie; Shutong Ren; Xian-E Peng

doi:10.1016/j.imj.2023.04.003

Association between Hepatitis B virus and gastric cancer: A systematic review and meta-analysis

Infect Med (Beijing). 2023 Apr 23;2(2):67-73. doi: 10.1016/j.imj.2023.04.003. eCollection 2023 Jun.

Authors

Rong Yu¹, Jingru Huang², Hewei Peng¹, Shuo Yin¹, Weijiang Xie¹, Shutong Ren¹, Xian-E Peng^{1

3}

Affiliations

¹ Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou 350122, China.
² Department of Clinical Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China.
³ Key Laboratory of Ministry of Education for Gastrointestinal Cancer, Fujian Medical University, Fuzhou 350108, China.

Abstract

An increasing number of studies are suggesting that hepatitis B virus (HBV) infection may be associated with an increased risk of not only hepatocellular carcinoma but also gastric cancer (GC). Whether HBV infection can be a risk factor for GC remains to be explored. In this study, we systematically searched for all eligible literature in 7 databases (China National Knowledge Infrastructure, WanFang, China Science and Technology Journal, PubMed, Cochrane Library, Web of Science and Embase). Eligible studies were required to have a case-control or cohort design. Sixteen studies were included and a meta-analysis was performed using Stata version 17.0. The quality of the included studies was assessed using the Newcastle-Ottawa Scale. The association between HBV infection and risk of GC was quantified by calculating the odds ratio and 95% confidence interval. The proportion of high-quality studies was 87.5% (14/16). The risk of GC was higher when HBV infection was present than when it was not (combined odds ratio 1.29, 95% confidence interval 1.16-1.44; I² = 62.7%, p < 0.001). The results of subgroup analyses were consistent with the main results. In conclusion, this systematic review and meta-analysis identified a positive association between HBV infection and an increased risk of GC.

Keywords: Gastric cancer; Hepatitis B virus; Meta-analysis.

Publication types

Review