Metabolic and senescence characteristics associated with the immune microenvironment in ovarian cancer

Front Endocrinol (Lausanne). 2023 Nov 22:14:1265525. doi: 10.3389/fendo.2023.1265525. eCollection 2023.

Abstract

Ovarian cancer is a highly malignant gynecological cancer influenced by the immune microenvironment, metabolic reprogramming, and cellular senescence. This review provides a comprehensive overview of these characteristics. Metabolic reprogramming affects immune cell function and tumor growth signals. Cellular senescence in immune and tumor cells impacts anti-tumor responses and therapy resistance. Targeting immune cell metabolism and inducing tumor cell senescence offer potential therapeutic strategies. However, challenges remain in identifying specific targets and biomarkers. Understanding the interplay of these characteristics can lead to innovative therapeutic approaches. Further research is needed to elucidate mechanisms, validate strategies, and improve patient outcomes in ovarian cancer.

Keywords: immune microenvironment; metabolism; ovarian cancer; senescence; therapeutic strategies.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cellular Senescence
  • Female
  • Humans
  • Ovarian Neoplasms*
  • Research Design
  • Tumor Microenvironment

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was funded by the Research foundation of Guangzhou Women and Children’s Medical Center for Clinical Doctor (2020BS027, 2021BS044), Plan on enhancing scientific research in GMU (02-410-2302169XM), and the Science and Technology Program of Guangzhou, China (2023A04J1244).