Latest advances in the study of non-coding RNA-mediated circadian rhythm disorders causing endometrial cancer

Ling-Tao Zheng; Shao-Rong Chen; Liang-Yu Zhou; Qiao-Yi Huang; Jia-Ming Chen; Wei-Hong Chen; Shu Lin; Qi-Yang Shi

doi:10.3389/fonc.2023.1277543

Latest advances in the study of non-coding RNA-mediated circadian rhythm disorders causing endometrial cancer

Front Oncol. 2023 Nov 22:13:1277543. doi: 10.3389/fonc.2023.1277543. eCollection 2023.

Authors

Ling-Tao Zheng^#¹, Shao-Rong Chen^#¹, Liang-Yu Zhou¹, Qiao-Yi Huang¹, Jia-Ming Chen¹, Wei-Hong Chen¹, Shu Lin^{2

3}, Qi-Yang Shi¹

Affiliations

¹ Department of Gynaecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
² Centre of Neurological and Metabolic Research, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, China.
³ Group of Neuroendocrinology, Garvan Institute of Medical Research, Sydney, NSW, Australia.

^# Contributed equally.

Abstract

Endometrial cancer (EC) is one of the most common gynecological cancers, and its risk factors include obesity and metabolic, genetic, and other factors. Recently, the circadian rhythm has also been shown to be associated with EC, as the severity of EC was found to be related to night work and rhythm disorders. Therefore, circadian rhythm disorders (CRDs) may be one of the metabolic diseases underlying EC. Changes in the circadian rhythm are regulated by clock genes (CGs), which in turn are regulated by non-coding RNAs (ncRNAs). More importantly, the mechanism of EC caused by ncRNA-mediated CRDs is gradually being unraveled. Here, we review existing studies and reports and explore the relationship between EC, CRDs, and ncRNAs.

Keywords: circadian rhythm disorders; clock genes; endometrial cancer; lncRNA; miRNA; non-coding RNAs.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Science and Technology Bureau of Quanzhou (grant number 2020CT003), the Science and Technology Bureau of Quanzhou (grant number 2020NO31s) and the Science and technology project of Fujian Provincial Health Commission (grant number 2020CXB027).