Facilitating diffusion tensor imaging of the brain during continuous gross head motion with first and second order motion compensating diffusion gradients

Abstract

Purpose: To demonstrate the feasibility of motion compensating diffusion gradient schemes in the acquisition of quality diffusion tensor images (DTI) of the brain during continuous gross head motion.

Methods: Five healthy subjects were scanned using a clinical 3 T MRI with and without continuous head motion. For one volunteer, DTI data was acquired using standard (M0) diffusion-weighted (DW) gradients, and first (M1) and second (M2) order gradient schemes that were previously developed for use in cardiac DTI. In four additional volunteers, DTI data was acquired with M0 and M2 gradients. DTI parameters were calculated and compared with established retrospective motion corrections.

Results: In the absence of motion, DTI parameters calculated from M0, M1, and M2 data were consistent. In the presence of motion, up to 44% of DW images acquired with M0 gradients were corrupted by signal dropout, compared to 0% of the M2 images. In voxelwise comparisons, DTI parameters calculated using motion-M0 data were elevated compared to reference data. Retrospective corrections for extreme motion applied to motion-M0 data did not improve consistency with reference data in cases where motion corrupted >15% of DW images. In contrast, DTI parameters calculated with motion-M2 data were consistent with reference data.

Conclusion: This proof-of-principle study demonstrates that motion compensating diffusion gradients can mitigate artifacts because of continuous motion in DTI of the brain and offers promise for improved DTI accessibility. Further study will be necessary to determine the robustness of the approach in patient populations with high susceptibility to head motion.

Keywords: brain; diffusion tensor imaging; motion compensation.