Reduced Ca2+ mobilization in neonatal human platelets involves SARAF and pannexin-1

Abstract

Platelets from neonates have been shown to exhibit a reduced response to physiological agonists, such as thrombin; however, the mechanism behind these findings is poorly understood. Berna-Erro et al. now provide differences in SARAF and pannexin-1 expression and function between neonatal and maternal platelets that might shed some light on the underlying mechanism. Commentary on: Berna-Erro. SARAF overexpression impairs thrombin-induced Ca²⁺ homeostasis in neonatal platelets. Br J Haematol 2024;204:988-1004.

Keywords: SARAF; STIM1; human platelets; neonates; pannexin-1.