Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate

Tingting Ma; Yijia Guan; Jinlun Feng; Yue Yang; Junying Chen; Wenjie Guo; Jianguo Liao; Yanru Zhang

doi:10.1186/s40824-023-00474-8

Osteogenic effect of magnesium oxychloride cement modified with phytic acid and loaded with strontium ranelate

Biomater Res. 2023 Dec 10;27(1):128. doi: 10.1186/s40824-023-00474-8.

Authors

Tingting Ma¹, Yijia Guan², Jinlun Feng¹, Yue Yang³, Junying Chen¹, Wenjie Guo¹, Jianguo Liao⁴, Yanru Zhang⁵

Affiliations

¹ Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, China.
² Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, China. guanyj@hpu.edu.cn.
³ School of Medicine, Henan Polytechnic University, Jiaozuo, China.
⁴ Henan Key Laboratory of Materials on Deep-Earth Engineering, School of Materials Science and Engineering, Henan Polytechnic University, Jiaozuo, China. liaojianguo10@hpu.edu.cn.
⁵ School of Medicine, Henan Polytechnic University, Jiaozuo, China. zyr@hpu.edu.cn.

Abstract

Background: Magnesium oxychloride cement has good mechanical properties, but poor water resistance.

Methods: Phytic acid, which can form chelate with Mg²⁺, was used to modify magnesium oxychloride cement, and the effects of phytic acid on the strength, in vitro degradation and biological activity of magnesium oxychloride cement were studied. Based on the preparation of phytic acid modified magnesium oxychloride cement with good water resistance and biological activity, osteoporosis treatment strontium ranelate was loaded on phytic acid- magnesium oxychloride cement, strontium ranelate/phytic acid-magnesium oxychloride cement was prepared.

Results: It was found that the compressive strength of 1.25 wt% phytic acid-magnesium oxychloride cement after soaking in SBF for 28 d could reach 40.5 ± 2.0 MPa, 13.33% higher than that of the control group (when phytic acid was 0 wt%), and the mass loss rate of all ages was lower than that of the control group. The water resistance of magnesium oxychloride cement was effectively improved by phytic acid. After loading with strontium ranelate, the water resistance of 1.25 wt% phytic acid-magnesium oxychloride cement was improved. Cell experiments showed that strontium ranelate could effectively promote cell proliferation and improve the expression of osteoblast-related proteins. When strontium ranelate/phytic acid-magnesium oxychloride cement samples were implanted subcutaneously in rats for 4 w, no obvious inflammatory response was observed, and the material was tightly bound to the surrounding tissues. When bone cement was implanted into rat femur for 4 w, the bone cement was gradually wrapped and absorbed by new bone tissue, which grew from the outside to the inside, indicating that the bone cement containing strontium ranelate/phytic acid-magnesium oxychloride cement had excellent bone-forming ability.

Conclusions: In conclusion, the results indicated that strontium ranelate/phytic acid-magnesium oxychloride cement composite bone cement had a potential application prospect in clinical bone repair.

Keywords: Magnesium oxychloride cement; Osteogenic property; Phytic acid; Strontium ranelate; Water resistance.

Abstract

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