Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception

Veit Mylius; Jan Harald Baars; Karsten Witt; David Benninger; Daniel Ciampi de Andrade; Georg Kägi; Julien F Bally; Florian Brugger

doi:10.1002/mds.29666

Deep Brain Stimulation Improves Parkinson's Disease-Associated Pain by Decreasing Spinal Nociception

Mov Disord. 2024 Feb;39(2):447-449. doi: 10.1002/mds.29666. Epub 2023 Dec 9.

Authors

Veit Mylius^{1

2

3}, Jan Harald Baars⁴, Karsten Witt^{5

6}, David Benninger⁷, Daniel Ciampi de Andrade⁸, Georg Kägi^{2

9}, Julien F Bally⁷, Florian Brugger²

Affiliations

¹ Department of Neurology, Center for Neurorehabilitation, Valens, Switzerland.
² Department of Neurology, Kantonsspital St. Gallen, St. Gallen, Switzerland.
³ Department of Neurology, Philipps University, Marburg, Germany.
⁴ Department of Anesthesia, Klinikum Neubrandenburg, Neubrandenburg, Germany.
⁵ Department of Neurology, School of Medicine and Health Sciences, Research Center Neurosensory Science, University of Oldenburg, Oldenburg, Germany.
⁶ Department of Neurology, Evangelic Hospital Oldenburg, Oldenburg, Germany.
⁷ Service of Neurology, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
⁸ Center for Neuroplasticity and Pain (CNAP), Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
⁹ Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.

PMID: 38071401
DOI: 10.1002/mds.29666

Abstract

Dopamine exerts antinociceptive effects on pain in PD at cortical and spinal levels, whereas only cortical effects have been described for DBS, so far. By assessing the nociceptive flexion reflex (NFR) threshold at medication on, and DBS ON and OFF in two patients, we showed that DBS additionally decreases spinal nociception.

Publication types

Letter

MeSH terms

Deep Brain Stimulation*
Humans
Nociception / physiology
Pain / etiology
Pain Measurement
Pain Threshold / physiology
Parkinson Disease* / complications
Parkinson Disease* / therapy