Background: The relationship between quality of life at three months after lung cancer surgery and different surgical approaches is remains unclear. This study aimed to compare the quality of life of patients three months after uniportal and multiportal thoracoscopic lobectomy.
Methods: Data from patients who underwent lung surgery at the Department of Thoracic Surgery, Sichuan Cancer Hospital between April 2021 and October 2021 were collected. The European Organization for Research and Treatment of Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) and Quality of Life Questionnaire-Lung Cancer 29 (EORTC QLQ-LC29) were used to collect quality of life data of the patients. Potential confounding factors in the baseline data were included in a multivariate regression model for adjustment, and the quality of life of the two groups three months postoperatively was compared with traditional clinical outcomes.
Results: A total of 130 lung cancer patients were included, with 57 males (43.8%) and 73 females (56.2%), and an average age of (57.1±9.5) yr. In the baseline data of the two groups, there was a statistical difference in the number of chest drainage tubes placed (P<0.001). After adjustment with the regression model, at three months postoperatively, there were no significant differences in all symptoms and functional status scores between the two groups (all P>0.05). The multiportal group had longer surgery time (120.0 min vs 85.0 min, P=0.001), postoperative hospital stay (6.0 d vs 4.0 d, P=0.020), and a higher incidence of early ≥ grade 2 complications (39.0% vs 10.1%, P=0.011) compared to the uniportal group.
Conclusions: Patients undergoing uniportal and multiportal thoracoscopic lobectomy have similar quality of life at three months postoperatively. The uniportal group may have certain advantages in terms of traditional clinical outcome indicators such as operation time, postoperative hospital stay, and early postoperative complications.
【中文题目：单孔与多孔胸腔镜肺叶切除术后3个月患者 生活质量比较】 【中文摘要：背景与目的 肺癌术后3个月的生活质量在不同手术入路之间的关系尚不明确，本研究旨在对比单孔与多孔胸腔镜肺叶切除术后3个月患者的生活质量。方法 收集2021年4月至2021年10月在四川省肿瘤医院胸外科行肺部手术患者的资料，采用欧洲癌症研究与治疗组织生活质量核心量表C30（European Organization for Research and Treatment of Cancer quality of life core 30, EORTC QLQ-C30）和肺癌生活质量量表29（Quality of Life Questionnaire-Lung Cancer 29, QLQ-LC29）收集患者的生活质量资料。将基线资料中潜在混杂因素纳入多因素回归模型中校正，比较两组患者术后3个月的生活质量与传统临床结局。结果 共纳入130例肺癌患者，男性57例（43.8%），女性73例（56.2%），平均年龄（57.1±9.5）岁。两组患者基线资料中，放置引流管数量具有统计学差异（P<0.001）。经回归模型校正后，在术后3个月时，两组患者全部症状及功能状态评分无明显差异（P均>0.05）。多孔组的手术时间（120.0 min vs 85.0 min, P=0.001）、术后住院时间（6.0 d vs 4.0 d, P=0.020）比单孔组更长，早期≥2级并发症发生率（39.0% vs 10.1%, P=0.011）比单孔组更高。结论 单孔与多孔胸腔镜肺叶切除术患者在术后3个月时具有相似的生活质量。单孔组在手术时间、术后住院时间及术后早期并发症等传统临床结局指标上可能具有一定的优势。 】 【中文关键词：肺肿瘤；单孔胸腔镜；多孔胸腔镜；生活质量；患者报告结局】.
Keywords: Lung neoplasms; Multiportal thoracoscopy; Patient-reported outcomes; Quality of life; Uniportal thoracoscopy.