Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

M J Hernández-Esparza; Ilaria Fratoddi; Sara Cerra; K Juarez-Moreno; R Huirache-Acuña

doi:10.1039/d3na00605k

Hybrid AuNPs-3MPS-MTX nanosystem and its evaluation for treating cervical cancer and melanoma

Nanoscale Adv. 2023 Nov 17;5(24):7077-7085. doi: 10.1039/d3na00605k. eCollection 2023 Dec 5.

Authors

M J Hernández-Esparza^{1

2}, Ilaria Fratoddi², Sara Cerra², K Juarez-Moreno³, R Huirache-Acuña¹

Affiliations

¹ Facultad de Ingeniería Química, Universidad Michoacana de San Nicolás de Hidalgo, Ciudad Universitaria C.P. 58060 Morelia Mexico rafael.huirache@umich.mx.
² Department of Chemistry, University Sapienza of Rome p. Aldo Moro 5 00185 Rome Italy.
³ Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México Mexico kjuarez@fata.unam.mx.

Abstract

This research presents an evaluation of a hybrid material based on gold nanoparticles (AuNPs), stabilized with the thiol 3-mercapto-propanesulfonate (3MPS) and loaded with the methotrexate drug (MTX). The AuNPs-3MPS-MTX nanosystem was tested for the treatment of cervical cancer and melanoma, using the B16-F10 melanoma and HeLa cell lines. The tests performed on cell cultures assessed the efficiency of the studied nanosystem on tumor cells, as well as its toxicology.