Zeaamine, a new amine from roots of Zea mays and its cytotoxic activity against CT26 and SW480 cell lines

Yunqiang Zhang; Weiguo Chen; Yiling Zhang; Xue Qiu; Yanhua Fan; Jianyu Liu; Andong Wang; Yongnan Xu

doi:10.1080/14786419.2023.2290149

Zeaamine, a new amine from roots of Zea mays and its cytotoxic activity against CT26 and SW480 cell lines

Nat Prod Res. 2023 Dec 5:1-7. doi: 10.1080/14786419.2023.2290149. Online ahead of print.

Authors

Yunqiang Zhang^{1

2}, Weiguo Chen³, Yiling Zhang^{1

2}, Xue Qiu^{1

2}, Yanhua Fan⁴, Jianyu Liu^{2

5}, Andong Wang⁶, Yongnan Xu^{2

5}

Affiliations

¹ School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China.
² Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, China.
³ School of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing, China.
⁴ State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, China.
⁵ School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
⁶ School of Pharmacy, Nantong University, Nantong, P. R. China.

PMID: 38050768
DOI: 10.1080/14786419.2023.2290149

Abstract

A new amine, zeaamine (1), along with nine known compounds (2-10), were isolated from the roots of Zea mays. Among these, compound 2 was first isolated from this plant, and compound 3 was first isolated from the roots. In the current investigation, the cytotoxicity against CT26 and SW480 cells of the compounds were evaluated. Zeaamine (1) exhibited moderately affected CT26 and SW480 cells with IC₅₀ values of 17.91 and 10.21 µM.

Keywords: CT26 and SW480 cells; Zeaamine; chemical constituents; cytotoxic activity; zea mays L.