Mechanistic Insights on Localized to Metastatic Prostate Cancer Transition and Therapeutic Opportunities

Res Rep Urol. 2023 Nov 29:15:519-529. doi: 10.2147/RRU.S386517. eCollection 2023.

Abstract

Prostate cancer is the most common non-cutaneous cancer among American men. Multiple mechanisms are involved in tumorigenesis and progression to metastases. While androgen deprivation therapy remains the cornerstone of treatment, progression to castration-resistant disease becomes inevitable. Aberrant pathway activations of PI3K/AKT due to PTEN loss, epithelial-mesenchymal transition pathways, homologous recombination repair, and DNA repair pathway mechanisms of resistance and cross-talk lead to opportunities for therapeutic targeting in metastatic castration-resistant prostate cancer. This review focuses on mechanisms of progression and key trials that evaluate the drugs and combinations that exploit these pathways.

Keywords: androgen receptor pathway inhibitors; castration-resistant prostate cancer; epithelial mesenchymal transition; metastasis; poly-ADP ribose pathway inhibitors; prostate cancer.

Publication types

  • Review

Grants and funding

Acknowledgement using the David Wohlscheid Fund.