NIR-responsive injectable magnesium phosphate bone cement loaded with icariin promotes osteogenesis

Abstract

There were defects like limited osteogenesis and fast drug release in traditional magnesium phosphate bone cement (MPC). In this study, we loaded icariin in a mesoporous nano silica container modified by polydopamine and then added it and citric acid into MPC (IHP-CA MPCs). The results indicate that IHP-CA MPCs have a long curing time, almost neutral pH value, excellent injectability, and compressive strength. In vitro experiments have shown that IHP-CA MPCs have good biocompatibility and bone promoting ability. These improvements provide feasible solutions and references for the clinical application of MPCs as implants.

Keywords: Icariin; Magnesium phosphate bone cement; Mesoporous silica nanoparticles; Near infrared response; Osteogenesis.