Progress in the clinical treatment of keloids

Wenli Qi; Xinyue Xiao; Jing Tong; Nengqiang Guo

doi:10.3389/fmed.2023.1284109

Progress in the clinical treatment of keloids

Front Med (Lausanne). 2023 Nov 16:10:1284109. doi: 10.3389/fmed.2023.1284109. eCollection 2023.

Authors

Wenli Qi^#¹, Xinyue Xiao^#¹, Jing Tong¹, Nengqiang Guo¹

Affiliation

¹ Department of Plastic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

^# Contributed equally.

Abstract

Keloid is a pathological scar that is higher than the skin surface following skin damage. Its lesion range often extends beyond the original damage boundary and does not naturally subside over time. Its pathogenesis is very complex, currently the main causes include fibroblast excessive proliferation, collagen and extracellular matrix (Extracellular matrix, ECM) excessive deposition, excessive angiogenesis, and so on. The traditional treatment method primarily involves surgical intervention, but it is associated with a high recurrence rate post-surgery. Consequently, many treatment methods are derived according to the different clinical characteristics of keloid. This paper will review the therapeutic progress in recent years from surgical treatment, physiotherapy, drug therapy, and biological therapy, with the goal of offering valuable insights for the clinical treatment of keloids.

Keywords: biological therapy; drug therapy; keloids; physical therapy; surgical therapy.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Hubei Province Knowledge Innovation Project (2019CFB561).