Alzheimer's Disease and Cancer: Common Targets

Xueqing Yang; Jinlian Dai; Chenglong Wu; Zongliang Liu

doi:10.2174/0113895575263108231031132404

Alzheimer's Disease and Cancer: Common Targets

Mini Rev Med Chem. 2023 Nov 21. doi: 10.2174/0113895575263108231031132404. Online ahead of print.

Authors

Xueqing Yang¹, Jinlian Dai¹, Chenglong Wu¹, Zongliang Liu¹

Affiliation

¹ School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, China.

PMID: 38037912
DOI: 10.2174/0113895575263108231031132404

Abstract

There is growing epidemiologic evidence of an inverse association between cancer and AD. In addition, both cell survival and death are regulated by the same signaling pathways, and their abnormal regulation may be implicated in the occurrence and development of cancer and AD. Research shows that there may be a common molecular mechanism between cancer and AD. This review will discuss the role of GSK3, DAPK1, PP2A, P53 and CB2R in the pathogenesis of cancer and AD and describe the current research status of drug development based on these targets.

Keywords: Alzheimer's disease; association; cancer; regulatory agent.; structure; target.