The lipid metabolism remodeling: A hurdle in breast cancer therapy

Qian Xiao; Min Xia; Weijian Tang; Hu Zhao; Yajun Chen; Jing Zhong

doi:10.1016/j.canlet.2023.216512

The lipid metabolism remodeling: A hurdle in breast cancer therapy

Cancer Lett. 2024 Feb 1:582:216512. doi: 10.1016/j.canlet.2023.216512. Epub 2023 Nov 28.

Authors

Qian Xiao¹, Min Xia², Weijian Tang³, Hu Zhao², Yajun Chen⁴, Jing Zhong⁵

Affiliations

¹ Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China; Department of Clinical Laboratory Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China.
² Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China.
³ Queen Mary School of Nanchang University, Nanchang University, Nanchang, 330031, PR China.
⁴ Department of Metabolism and Endocrinology, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China. Electronic address: pine1111@163.com.
⁵ Cancer Research Institute, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China; Institute of Clinical Medicine, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, 421001, PR China. Electronic address: zhongjing2002@usc.edu.cn.

PMID: 38036043
DOI: 10.1016/j.canlet.2023.216512

Abstract

Lipids, as one of the three primary energy sources, provide energy for all cellular life activities. Lipids are also known to be involved in the formation of cell membranes and play an important role as signaling molecules in the intracellular and microenvironment. Tumor cells actively or passively remodel lipid metabolism, using the function of lipids in various important cellular life activities to evade therapeutic attack. Breast cancer has become the leading cause of cancer-related deaths in women, which is partly due to therapeutic resistance. It is necessary to fully elucidate the formation and mechanisms of chemoresistance to improve breast cancer patient survival rates. Altered lipid metabolism has been observed in breast cancer with therapeutic resistance, indicating that targeting lipid reprogramming is a promising anticancer strategy.

Keywords: Breast cancer; Lipid metabolism; Targeting therapy; Therapy resistance.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Breast / pathology
Breast Neoplasms* / pathology
Female
Humans
Lipid Metabolism
Lipids
Tumor Microenvironment

Substances

Lipids