GPR35 acts a dual role and therapeutic target in inflammation

Yetian Wu; Pei Zhang; Hongjie Fan; Caiying Zhang; Pengfei Yu; Xinmiao Liang; Yang Chen

doi:10.3389/fimmu.2023.1254446

GPR35 acts a dual role and therapeutic target in inflammation

Front Immunol. 2023 Nov 16:14:1254446. doi: 10.3389/fimmu.2023.1254446. eCollection 2023.

Authors

Yetian Wu^#¹, Pei Zhang^#², Hongjie Fan¹, Caiying Zhang¹, Pengfei Yu¹, Xinmiao Liang^{1

3}, Yang Chen^{1

3}

Affiliations

¹ Ganjiang Chinese Medicine Innovation Center, Nanchang, China.
² Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, MD, United States.
³ CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.

^# Contributed equally.

Abstract

GPR35 is a G protein-coupled receptor with notable involvement in modulating inflammatory responses. Although the precise role of GPR35 in inflammation is not yet fully understood, studies have suggested that it may have both pro- and anti-inflammatory effects depending on the specific cellular environment. Some studies have shown that GPR35 activation can stimulate the production of pro-inflammatory cytokines and facilitate the movement of immune cells towards inflammatory tissues or infected areas. Conversely, other investigations have suggested that GPR35 may possess anti-inflammatory properties in the gastrointestinal tract, liver and certain other tissues by curbing the generation of inflammatory mediators and endorsing the differentiation of regulatory T cells. The intricate role of GPR35 in inflammation underscores the requirement for more in-depth research to thoroughly comprehend its functional mechanisms and its potential significance as a therapeutic target for inflammatory diseases. The purpose of this review is to concurrently investigate the pro-inflammatory and anti-inflammatory roles of GPR35, thus illuminating both facets of this complex issue.

Keywords: GPR35; anti-inflammatory; inflammatory diseases; pro-inflammatory; therapeutic target.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / therapeutic use
Humans
Inflammation*
Receptors, G-Protein-Coupled*

Substances

Receptors, G-Protein-Coupled
Anti-Inflammatory Agents
GPR35 protein, human

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Natural Science Foundation of Jiangxi, China (20232BBH80012, 20224ACB216012), Natural Science Foundation of Liaoning, China (2022-MS-017) and Dalian High-Level Talent Support Program (2021RQ003).