Gut microbiome, metabolome and alopecia areata

Zhiyu Liu; Xiaoyan Liu

doi:10.3389/fmicb.2023.1281660

Gut microbiome, metabolome and alopecia areata

Front Microbiol. 2023 Nov 15:14:1281660. doi: 10.3389/fmicb.2023.1281660. eCollection 2023.

Authors

Zhiyu Liu¹, Xiaoyan Liu²

Affiliations

¹ School of Medicine of Zhejiang University, Hangzhou, China.
² Department of Dermatology, The First Affiliated Hospital, School of Medicine of Zhejiang University, Hangzhou, China.

Abstract

Alopecia areata (AA) is a type of dermatological disease characterized by rapid and non-scarring hair loss of the scalp or body skin that may be related to genetic, immunological and physiological factors. It is now believed that AA is associated with oxidative stress, autoimmune disease, neuropsychological factors, pathogens, immune checkpoint inhibitors and microecological imbalance under the premise of host genetic susceptibility. In recent years, studies have revealed the significant role of the gut microbiome or metabolome in many aspects of human health. Diverse studies have revealed that the gut microbiome and metabolome have an important influence on skin conditions. This review highlights the relationship between AA and the gut microbiome or metabolome to provide novel directions for the prevention, clinical diagnosis and treatment of AA.

Keywords: JAK–STAT signaling; TGF-β signaling; Wnt/β-catenin signaling; alopecia areata; gut microbiome; metabolome; oxidative stress.

Publication types

Review

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Natural Science Foundation of Zhejiang Province (LY22H110001).