Minimally invasive enucleation of pancreatic tumors: The main pancreatic duct is no longer a restricted area

Zheng Li; Qifeng Zhuo; Yihua Shi; Haidi Chen; Mengqi Liu; Wensheng Liu; Wenyan Xu; Chen Chen; Shunrong Ji; Xianjun Yu; Xiaowu Xu

doi:10.1016/j.heliyon.2023.e21917

Minimally invasive enucleation of pancreatic tumors: The main pancreatic duct is no longer a restricted area

Heliyon. 2023 Nov 7;9(11):e21917. doi: 10.1016/j.heliyon.2023.e21917. eCollection 2023 Nov.

Authors

Zheng Li^{1

2

3

4}, Qifeng Zhuo^{1

2

3

4}, Yihua Shi^{1

2

3

4}, Haidi Chen^{1

2

3

4}, Mengqi Liu^{1

2

3

4}, Wensheng Liu^{1

2

3

4}, Wenyan Xu^{1

2

3

4}, Chen Chen^{1

2

3

4}, Shunrong Ji^{1

2

3

4}, Xianjun Yu^{1

2

3

4}, Xiaowu Xu^{1

2

3

4}

Affiliations

¹ Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai, 200032, China.
² Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
³ Shanghai Pancreatic Cancer Institute, Shanghai, 200032, China.
⁴ Pancreatic Cancer Institute, Fudan University, Shanghai, 200032, China.

Abstract

Background: Tumors involving the main pancreatic duct (MPD) used to be a contraindication for enucleation.

Methods: Clinical data of consecutive patients with pancreatic tumors who received laparoscopic or robotic enucleation (LEN or REN) between January 2019 and December 2021 at Fudan University Shanghai Cancer Center were analyzed.

Results: Ninety-six patients were included in the analysis, with 55 in the LEN group and 41 in the REN group, and no conversion to laparotomy. Most tumors were located in the head of pancreas (71.9 %). The tumor diameter (3.1 vs. 1.9 cm) was larger, and more cystic tumors (92.7 % vs. 56.4 %) and more tumors involving the MPD (34.1 % vs. 3.6 %) were observed in the REN group. MPD support tube insertion was performed in 15 cases, with 11 in the REN group and 4 in the LEN group. The incidence of biochemical and grade B postoperative pancreatic fistula (POPF) was both 46.9 %, and no grade C POPF occurred. Among the 45 patients with grade B POPF, 28 cases (62.2 %) were due to carrying drainage tube >3 weeks without additional treatment, and only 4 cases required invasive treatment. For patients with MPD support tube implantation (n = 15), support tube fall-offs were observed in 12 cases, 2 patients had MPD dilatation, and no MPD stricture, stone formation or pancreatic atrophy was observed during follow-up.

Conclusions: The incidence of POPF was high but still controllable without serious complications after minimally invasive enucleation. The MPD is no longer a restricted area, and the robotic system has advantages in handling complex enucleations.

Keywords: Long-term prognosis; Main pancreatic duct; Minimally invasive enucleation; Pancreatic fistula; Pancreatic tumors; Robotic system.