The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia

Xuezhi Rao; Zhijie Xu; Jingchun Zhang; Jiaxiang Zhou; Jian Huang; Zhanhao Toh; Ruwen Zheng; Zhiyu Zhou

doi:10.3389/fendo.2023.1290639

The causal relationship between sarcopenic obesity factors and benign prostate hyperplasia

Front Endocrinol (Lausanne). 2023 Nov 8:14:1290639. doi: 10.3389/fendo.2023.1290639. eCollection 2023.

Authors

Xuezhi Rao^#^{1

2}, Zhijie Xu^#^{1

3}, Jingchun Zhang⁴, Jiaxiang Zhou⁵, Jian Huang⁶, Zhanhao Toh⁷, Ruwen Zheng⁶, Zhiyu Zhou^{8

9}

Affiliations

¹ Beijing University of Chinese Medicine, Beijing, China.
² The Second School of Clinical Medicine, Beijing University of Chinese Medicine, Beijing, China.
³ Graduate School, Beijing University of Chinese Medicine, Beijing, China.
⁴ Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
⁵ Department of Spinal Surgery, The Affiliated Hospital of Qingdao University, Qingdao, China.
⁶ Department of Acupuncture and Moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
⁷ Singa Care Medical, Singapore, Singapore.
⁸ Innovation Platform of Regeneration and Repair of Spinal Cord and Nerve Injury, Department of Orthopaedic Surgery, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China.
⁹ Guangdong Provincial Key Laboratory of Orthopedics and Traumatology, Orthopaedic Research Institute/Department of Spinal Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

^# Contributed equally.

Abstract

Background: Both benign prostatic hyperplasia (BPH) and sarcopenic obesity (SO) are common conditions among older adult/adults males. The prevalent lifestyle associated with SO is a significant risk factor for the development of BPH. Therefore, we investigated the causal relationship between SO factors and BPH.

Method: The instrumental variables for SO factors were selected using the inverse variance-weighted method, which served as the primary approach for Mendelian randomization analysis to assess the causal effect based on summary data derived from genome-wide association studies of BPH.

Result: The increase in BMR (OR = 1.248; 95% CI = (1.087, 1.432); P = 0.002) and ALM (OR = 1.126; 95% CI = (1.032, 1.228); P = 0.008) was found to be associated with an elevated risk of BPH. However, no genetic causality between fat-free mass distribution, muscle mass distribution, and BPH was observed.

Conclusion: Our findings indicate that a genetic causal association between BMR, ALM and BPH. BMR and ALM are risk factors for BPH. The decrease in BMR and ALM signified the onset and progression of SO, thus SO is a protective factor for BPH.

Keywords: appendicular lean mass; basal metabolic rate; benign prostatic hyperplasia; genome-wide association study; mendelian randomization; sarcopenic obesity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Genome-Wide Association Study
Humans
Hyperplasia / complications
Male
Obesity / complications
Prostate
Prostatic Hyperplasia* / complications
Prostatic Hyperplasia* / genetics
Sarcopenia* / complications

Grants and funding

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was financially supported by the National Natural Science Foundation of China (U22A20162, 31900583, 32071351, 81772400, 82102604, 81960395, 81904287); foundation of Shenzhen Committee for Science and Technology Innovation (JCYJ20190809142211354), Sanming Project of Medicine in Shenzhen (SZSM201911002).