Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Sandra Cotino-Nájera; Luis A Herrera; Guadalupe Domínguez-Gómez; José Díaz-Chávez

doi:10.3389/fphar.2023.1287505

Molecular mechanisms of resveratrol as chemo and radiosensitizer in cancer

Front Pharmacol. 2023 Nov 10:14:1287505. doi: 10.3389/fphar.2023.1287505. eCollection 2023.

Authors

Sandra Cotino-Nájera¹, Luis A Herrera^{1

2}, Guadalupe Domínguez-Gómez³, José Díaz-Chávez⁴

Affiliations

¹ Laboratorio de Oncología Molecular, Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN), Ciudad de México, Mexico.
² Escuela de Medicina y Ciencias de la Salud-Tecnológico de Monterrey, México City, Mexico.
³ Subdirección de Investigación Clínica, Instituto Nacional de Cancerología (INCAN), Ciudad de México, Mexico.
⁴ Unidad de Investigación en Cáncer, Instituto de Investigaciones Biomédicas-Universidad Nacional Autónoma de México, Instituto Nacional de Cancerología, Ciudad de México, Mexico.

Abstract

One of the primary diseases that cause death worldwide is cancer. Cancer cells can be intrinsically resistant or acquire resistance to therapies and drugs used for cancer treatment through multiple mechanisms of action that favor cell survival and proliferation, becoming one of the leading causes of treatment failure against cancer. A promising strategy to overcome chemoresistance and radioresistance is the co-administration of anticancer agents and natural compounds with anticancer properties, such as the polyphenolic compound resveratrol (RSV). RSV has been reported to be able to sensitize cancer cells to chemotherapeutic agents and radiotherapy, promoting cancer cell death. This review describes the reported molecular mechanisms by which RSV sensitizes tumor cells to radiotherapy and chemotherapy treatment.

Keywords: cancer; chemoresistance; molecular mechanisms; radioresistance; resveratrol.

Publication types

Review

Grants and funding

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