Multimode microdimer robot for crossing tissue morphological barrier

Haocheng Wang; Chenlu Liu; Xiaopeng Yang; Fengtong Ji; Wenping Song; Guangyu Zhang; Lin Wang; Yanhe Zhu; Shimin Yu; Weiwei Zhang; Tianlong Li

doi:10.1016/j.isci.2023.108320

Multimode microdimer robot for crossing tissue morphological barrier

iScience. 2023 Oct 28;26(11):108320. doi: 10.1016/j.isci.2023.108320. eCollection 2023 Nov 17.

Authors

Haocheng Wang¹, Chenlu Liu¹, Xiaopeng Yang¹, Fengtong Ji², Wenping Song^{1

3}, Guangyu Zhang¹, Lin Wang¹, Yanhe Zhu¹, Shimin Yu⁴, Weiwei Zhang⁵, Tianlong Li^{1

3}

Affiliations

¹ State Key Laboratory of Robotics and System, Harbin Institute of Technology, Harbin, China.
² Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, UK.
³ Chongqing Research Institute of Harbin Institute of Technology Chongqing, Chongqing, China.
⁴ College of Engineering, Ocean University of China, Qingdao, China.
⁵ School of Mechanical and Power Engineering, Zhengzhou University, Zhengzhou, China.

Abstract

Swimming microrobot energized by magnetic fields exhibits remotely propulsion and modulation in complex biological experiment with high precision. However, achieving high environment adaptability and multiple tasking capability in one configuration is still challenging. Here, we present a strategy that use oriented magnetized Janus spheres to assemble the microdimer robots with two magnetic distribution configurations of head-to-side configuration (HTS-config) and head-to-head configuration (HTH-config), achieving performance of multiple tasks through multimode transformation and locomotion. Modulating the magnetic frequency enables multimode motion transformation between tumbling, rolling, and swing motion with different velocities. The dual-asynchronization mechanisms of HTS-config and HTH-config robot dependent on magnetic dipole-dipole angle are investigated by molecular dynamic simulation. In addition, the microdimer robot can transport cell crossing morphological rugae or complete drug delivery on tissues by switching motion modes. This microdimer robot can provide versatile motion modes to address environmental variations or multitasking requirements.

Keywords: Materials application; Materials physics.