The Expression and Function of Piezo Channels in Bladder

Zhipeng Li; Dongxu Lin; Changcheng Luo; Pengyu Wei; Bolang Deng; Kang Li; Langqing Cheng; Zhong Chen

doi:10.14440/bladder.2023.870

The Expression and Function of Piezo Channels in Bladder

Bladder (San Franc). 2023 Oct 30:10:e21200008. doi: 10.14440/bladder.2023.870. eCollection 2023.

Authors

Zhipeng Li^{1

2}, Dongxu Lin^{1

2}, Changcheng Luo^{1

2}, Pengyu Wei^{1

2}, Bolang Deng^{1

2}, Kang Li^{1

2}, Langqing Cheng^{1

2}, Zhong Chen^{1

2}

Affiliations

¹ Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.
² Institute of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China.

Abstract

The ability for bladder to perceive and analyze mechanical stimuli, such as stretch and filling, is crucial for its functions, such as urinary storage and voiding. The Piezo channel family, including Piezo1 and Piezo2, represents one of the most essential mechanosensitive ion channels in mammals and is involved in a wide array of physiological and pathological processes. It has been demonstrated in numerous investigations that Piezo channels play a key role in mechanical transduction in various types of cells in bladder by converting mechanical stimuli into biological signals. Notably, mounting evidence suggests that Piezo channels are functionally significant for bladder and are related to several bladder disorders. This review systematically summarizes the importance/role and features of Piezo channels in bladder, including their biophysical properties, location, and functions, with attention specifically paid to their association with the physiology and pathophysiology of bladder. This review aims to provide a novel perspective for the future clinical treatment of bladder dysfunction.

Keywords: Bladder dysfunction; Mechanosensitive cation channels; Piezo channels.

Publication types

Review