Cushing Syndrome due to Adrenocortical Carcinoma During Pregnancy

Jack Andrew Morris; Peter Campbell; Lily Xu; Anthony John O'Sullivan

doi:10.1210/jcemcr/luad118

Cushing Syndrome due to Adrenocortical Carcinoma During Pregnancy

JCEM Case Rep. 2023 Nov 16;1(6):luad118. doi: 10.1210/jcemcr/luad118. eCollection 2023 Nov.

Authors

Jack Andrew Morris¹, Peter Campbell², Lily Xu³, Anthony John O'Sullivan^{3

4}

Affiliations

¹ Endocrinologist, Shoalhaven Hospital, Nowra, NSW, 2541, Australia.
² Breast Endocrine Surgeon, St. George Hospital, Kogarah, NSW, 2217, Australia.
³ Department of Endocrinology, St. George Hospital, Kogarah, NSW, 2217, Australia.
⁴ Professor of Medicine, St George and Sutherland Campus, School of Clinical Medicine, UNSW Sydney, Kogarah, NSW, 2217, Australia.

Abstract

Cushing syndrome resulting from adrenocortical carcinoma in pregnancy is exceedingly rare. There are no validated guidelines to establish a diagnosis or guide management in pregnancy. We provide a case of a 31-year-old woman presenting for management of diabetes in pregnancy who appeared cushingoid. She was subsequently diagnosed with ACTH-independent Cushing syndrome and experienced preterm labor at 33 weeks' gestation, delivering a healthy infant. Four weeks postpartum, the patient underwent a left adrenalectomy and was subsequently diagnosed with adrenocortical carcinoma.

Keywords: Cushing syndrome; adrenocortical carcinoma; pregnancy.

Publication types

Case Reports