Epidemiology, Clinical Characteristics and Cause-specific Outcomes in Heart Failure with Preserved Ejection Fraction

Chris J Kapelios; Bahira Shahim; Lars H Lund; Gianluigi Savarese

doi:10.15420/cfr.2023.03

Epidemiology, Clinical Characteristics and Cause-specific Outcomes in Heart Failure with Preserved Ejection Fraction

Card Fail Rev. 2023 Nov 17:9:e14. doi: 10.15420/cfr.2023.03. eCollection 2023.

Authors

Chris J Kapelios¹, Bahira Shahim², Lars H Lund², Gianluigi Savarese²

Affiliations

¹ Department of Cardiovascular Medicine, University of Utah Health Sciences Center Salt Lake City, UT, US.
² Unit of Cardiology, Department of Medicine, Karolinska Institutet, and Heart and Vascular Theme, Karolinska University Hospital Stockholm, Sweden.

Abstract

Heart failure (HF) is a global pandemic affecting 64 million people worldwide. HF with preserved ejection fraction (HFpEF) has traditionally received less attention than its main counterpart, HF with reduced ejection fraction (HFrEF). The incidence and prevalence of HFpEF show geographic variation and are increasing over time, soon expected to surpass those of HFrEF. Morbidity and mortality rates of HFpEF are considerable, albeit lower than those of HFrEF. This review focuses on the burden of HFpEF, providing contemporary data on epidemiology, clinical characteristics and comorbidities, cause-specific outcomes, costs and pharmacotherapy.

Keywords: Mortality; costs; heart failure; hospitalisations; left ventricular ejection fraction.

Publication types

Review