Kristen rat sarcoma virus (KRAS) G12F-positive non-small cell lung cancer mimicking KRAS G12C positivity: A case report

Issei Oi; Takanori Ito; Zentaro Saito; Takuma Imakita; Osamu Kanai; Kohei Fujita; Hiromasa Tachibana; Tadashi Mio

doi:10.1111/1759-7714.15171

Kristen rat sarcoma virus (KRAS) G12F-positive non-small cell lung cancer mimicking KRAS G12C positivity: A case report

Thorac Cancer. 2024 Jan;15(3):271-273. doi: 10.1111/1759-7714.15171. Epub 2023 Nov 27.

Authors

Issei Oi¹, Takanori Ito¹, Zentaro Saito¹, Takuma Imakita¹, Osamu Kanai¹, Kohei Fujita¹, Hiromasa Tachibana¹, Tadashi Mio¹

Affiliation

¹ Division of Respiratory Medicine, Center of Respiratory Diseases, National Hospital Organization Kyoto Medical Center, Kyoto, Japan.

Abstract

Searching for driver gene alteration is a prerequisite for chemotherapy of non-small cell lung cancer. Due to its high sensitivity and concordance rate, the Amoy Dx Pan Lung Cancer PCR panel has been approved and is widely used in Japan. In this report, we describe a case in which a positive result for Kristen rat sarcoma virus (KRAS) exon2 p.G12F, a rare KRAS mutation, may have led to a false-positive result for KRAS exon2 p.G12C on AMOY. Genetic analysis in this case was performed by LC-SCRUM-Asia.

Keywords: AMOY; G12C; G12F; KRAS.

Publication types

Case Reports

MeSH terms

Carcinoma, Non-Small-Cell Lung* / genetics
Humans
Japan
Lung Neoplasms* / genetics
Mutation
Proto-Oncogene Proteins p21(ras) / genetics
Sarcoma*

Substances

Proto-Oncogene Proteins p21(ras)
KRAS protein, human