The use of flexible molecular systems in solution, without strictly controlling their behaviour, has frequently been productive. Their potential could increase by a more holistic view of the reaction(s) process(es) in which they are involved. In this perspective, we introduce a broader approach - "Chemical Chartographisis" - and discuss three projects in detail to illustrate its potential. The topics involve bimetallic 3d/4f species and coordination compounds built from benzotriazole-based and (a)symmetric salan ligands and focus on catalytic and, in less detail, biological-related examples.