Practical Considerations for Total-Body PET Acquisition and Imaging

Benjamin A Spencer; Kristin McBride; Heather Hunt; Terry Jones; Simon R Cherry; Ramsey D Badawi

doi:10.1007/978-1-0716-3499-8_21

Practical Considerations for Total-Body PET Acquisition and Imaging

Methods Mol Biol. 2024:2729:371-389. doi: 10.1007/978-1-0716-3499-8_21.

Authors

Benjamin A Spencer^{1

2}, Kristin McBride³, Heather Hunt³, Terry Jones³, Simon R Cherry^{3

4}, Ramsey D Badawi^{3

4}

Affiliations

¹ Department of Radiology, University of California-Davis, Sacramento, CA, USA. benspencer@ucdavis.edu.
² Department of Biomedical Engineering, University of California-Davis, Davis, CA, USA. benspencer@ucdavis.edu.
³ Department of Radiology, University of California-Davis, Sacramento, CA, USA.
⁴ Department of Biomedical Engineering, University of California-Davis, Davis, CA, USA.

PMID: 38006507
DOI: 10.1007/978-1-0716-3499-8_21

Abstract

The world's first total-body PET/CT system has been in routine clinical and research use at UC Davis since 2019. The uEXPLORER total-body PET scanner has been designed with an axial field-of-view long enough to completely encompass most human subjects (194 cm or 76 inches long), allowing for a 15-68-fold gain in the PET signal collection efficiency over conventional PET scanners. A high-sensitivity PET scanner that can image the entire subject with a single bed position comes with new benefits and challenges to consider for efficient and practical use. In this chapter, we discuss the common clinical and research imaging protocols implemented at our institution, along with the appropriate technical and practical considerations of total-body PET imaging.

Keywords: Dynamic PET; EXPLORER; Human imaging; Long axial FOV; Low dose imaging; PET; Total-body imaging.

MeSH terms

Humans
Positron Emission Tomography Computed Tomography*
Positron-Emission Tomography / methods
Whole Body Imaging* / methods