Radiolabeled Affibody Molecules for PET Imaging

Chiara Da Pieve; Gabriela Kramer-Marek

doi:10.1007/978-1-0716-3499-8_10

Radiolabeled Affibody Molecules for PET Imaging

Methods Mol Biol. 2024:2729:159-182. doi: 10.1007/978-1-0716-3499-8_10.

Authors

Chiara Da Pieve¹, Gabriela Kramer-Marek²

Affiliations

¹ Preclinical Molecular Imaging, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK.
² Preclinical Molecular Imaging, Division of Radiotherapy and Imaging, The Institute of Cancer Research, London, UK. Gabriela.Kramer-Marek@icr.ac.uk.

PMID: 38006496
DOI: 10.1007/978-1-0716-3499-8_10

Abstract

Owing to their ease of engineering and production, chemical stability, size, and high target affinity and specificity, radiolabeled affibody molecules have been recognized as very promising molecular imaging probes in both preclinical and clinical settings. Herein we describe the methods for the preparation of affibody-chelator conjugates and their subsequent radiolabeling with ¹⁸F-AlF, ⁶⁸Ga, ⁸⁹Zr.

Keywords: 18F-AlF; 68Ga; 89Zr; Conjugation; chelators.

MeSH terms

Cell Line, Tumor
Chelating Agents* / chemistry
Positron-Emission Tomography* / methods

Substances

Chelating Agents