Paraneoplastic Dermatoses and Cutaneous Metastases

Andrea Murina; Ashley Allen

doi:10.1016/j.cger.2023.09.005

Paraneoplastic Dermatoses and Cutaneous Metastases

Clin Geriatr Med. 2024 Feb;40(1):177-195. doi: 10.1016/j.cger.2023.09.005. Epub 2023 Oct 13.

Authors

Andrea Murina¹, Ashley Allen²

Affiliations

¹ Department of Dermatology, Tulane University School of Medicine, 1430 Tulane Avenue #8036, New Orleans, LA 70112, USA. Electronic address: amurina@tulane.edu.
² Department of Dermatology, Tulane University School of Medicine, 1430 Tulane Avenue #8036, New Orleans, LA 70112, USA.

PMID: 38000859
DOI: 10.1016/j.cger.2023.09.005

Abstract

Paraneoplastic syndromes include a variety of cutaneous presentations that have an associated internal malignancy. Some syndromes have a strong correlation to specific internal malignancies, whereas others are associated with a multitude of tumors. There are many cutaneous manifestations that suggest hematologic disorders, which will be reviewed in detail. Cutaneous metastases are commonly from breast and lung cancers and can present as nodules, vascular lesions, eczematous dermatitis, or inflammatory lesions. The most common histologic presentation of cutaneous metastasis is that of a dermal-based or subcutaneous-based nodule with sparing of the epidermis. Determination of origin of tumor requires immunohistochemistry and clinical correlation.

Keywords: Cutaneous; Malignancy; Metastasis; Paraneoplastic.

Publication types

Review

MeSH terms

Humans
Lung Neoplasms* / diagnosis
Paraneoplastic Syndromes* / diagnosis
Paraneoplastic Syndromes* / etiology
Skin Diseases* / diagnosis
Skin Diseases* / etiology
Skin Diseases* / pathology
Skin Neoplasms* / diagnosis
Skin Neoplasms* / pathology