Narcolepsy and psychiatric disorders: A bidirectional Mendelian randomization study

Biao Li; Zibo Gao; Yue He; Yuyang Tian; Yuxuan Shen; Ge Yu; Xiaohan Geng; Changgui Kou

doi:10.1016/j.jpsychires.2023.11.034

Narcolepsy and psychiatric disorders: A bidirectional Mendelian randomization study

J Psychiatr Res. 2024 Jan:169:42-48. doi: 10.1016/j.jpsychires.2023.11.034. Epub 2023 Nov 21.

Authors

Biao Li¹, Zibo Gao², Yue He³, Yuyang Tian⁴, Yuxuan Shen⁵, Ge Yu⁶, Xiaohan Geng⁷, Changgui Kou⁸

Affiliations

¹ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: libiao21@mails.jlu.edu.cn.
² Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: gaozb21@mails.jlu.edu.cn.
³ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: heyue21@mails.jlu.edu.cn.
⁴ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: tianyy21@mails.jlu.edu.cn.
⁵ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: syx21@mails.jlu.edu.cn.
⁶ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: geyu21@mails.jlu.edu.cn.
⁷ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: gengxh22@mails.jlu.edu.cn.
⁸ Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, No.1163 Xinmin Street, Changchun, Jilin, 130021, China. Electronic address: koucg@jlu.edu.cn.

PMID: 38000183
DOI: 10.1016/j.jpsychires.2023.11.034

Abstract

Since the introduction of the concept of narcolepsy, there has been a proliferation of discussions about its association with psychiatry. To elucidate the causal role of narcolepsy in the three psychiatric disorders [i.e., schizophrenia (SCZ), major depressive disorder (MDD), and attention-deficit hyperactivity disorder (ADHD)], we applied a bidirectional Mendelian randomization study using two stages (discovery stage and validation stage) and data from three different genome-wide association studies of narcolepsy. The estimates from different stages were combined using fixed-effects meta-analysis. Our findings suggest that narcolepsy is associated with an increased risk of SCZ. Conversely, MDD may be causally related to narcolepsy. A causal relationship between narcolepsy and ADHD was excluded.

Keywords: Causality; Mendelian randomization; Narcolepsy; Psychiatric disorder.

Publication types

Meta-Analysis

MeSH terms

Attention Deficit Disorder with Hyperactivity* / complications
Depressive Disorder, Major* / complications
Depressive Disorder, Major* / epidemiology
Depressive Disorder, Major* / genetics
Genome-Wide Association Study
Humans
Mendelian Randomization Analysis
Narcolepsy* / complications
Narcolepsy* / epidemiology
Narcolepsy* / genetics