Material and Design Toolkit for Drug Delivery: State of the Art, Trends, and Challenges

ACS Appl Mater Interfaces. 2023 Dec 6;15(48):55201-55231. doi: 10.1021/acsami.3c10065. Epub 2023 Nov 23.

Abstract

The nanomaterial and related toolkit have promising applications for improving human health and well-being. Nanobased drug delivery systems use nanoscale materials as carriers to deliver therapeutic agents in a targeted and controlled manner, and they have shown potential to address issues associated with conventional drug delivery systems. They offer benefits for treating various illnesses by encapsulating or conjugating biological agents, chemotherapeutic drugs, and immunotherapeutic agents. The potential applications of this technology are vast; however, significant challenges exist to overcome such as safety issues, toxicity, efficacy, and insufficient capacity. This article discusses the latest developments in drug delivery systems, including drug release mechanisms, material toolkits, related design molecules, and parameters. The concluding section examines the limitations and provides insights into future possibilities.

Keywords: drug delivery systems; nanoparticles; release mechanisms; surface modification; targeted delivery.

Publication types

  • Review

MeSH terms

  • Drug Carriers
  • Drug Delivery Systems
  • Humans
  • Nanoparticles*
  • Nanostructures*

Substances

  • Drug Carriers