Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children's study

Kazuma Tagami; Noriyuki Iwama; Hirotaka Hamada; Hasumi Tomita; Rie Kudo; Natsumi Kumagai; Naoto Sato; Seiya Izumi; Kasumi Sakurai; Zen Watanabe; Mami Ishikuro; Taku Obara; Nozomi Tatsuta; Tetsuro Hoshiai; Hirohito Metoki; Masatoshi Saito; Junichi Sugawara; Shinichi Kuriyama; Takahiro Arima; Nobuo Yaegashi; Japan Environment and Children's Study Group

doi:10.1016/j.preghy.2023.11.002

Maternal birth weight as an indicator of early-onset and late-onset hypertensive disorders of pregnancy: The Japan Environment and Children's study

Pregnancy Hypertens. 2023 Dec:34:159-168. doi: 10.1016/j.preghy.2023.11.002. Epub 2023 Nov 22.

Authors

Kazuma Tagami¹, Noriyuki Iwama², Hirotaka Hamada¹, Hasumi Tomita¹, Rie Kudo¹, Natsumi Kumagai¹, Naoto Sato¹, Seiya Izumi¹, Kasumi Sakurai³, Zen Watanabe¹, Mami Ishikuro⁴, Taku Obara⁴, Nozomi Tatsuta³, Tetsuro Hoshiai¹, Hirohito Metoki⁵, Masatoshi Saito⁶, Junichi Sugawara⁷, Shinichi Kuriyama⁸, Takahiro Arima³, Nobuo Yaegashi⁷; Japan Environment and Children's Study Group

Affiliations

¹ Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1, Seiryomachi, Sendai 980-8574, Miyagi, Japan.
² Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1, Seiryomachi, Sendai 980-8574, Miyagi, Japan; Division of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryomachi, Sendai 980-8573, Miyagi, Japan. Electronic address: noriyuki.iwama@med.tohoku.ac.jp.
³ Environment and Genome Research Center, Tohoku University Graduate School of Medicine, 2-1, Seiryomachi, Sendai 980-8575, Miyagi, Japan.
⁴ Division of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryomachi, Sendai 980-8573, Miyagi, Japan; Division of Molecular Epidemiology, Tohoku University Graduate School of Medicine, 2-1, Seiryomachi, Sendai 980-8575, Miyagi, Japan.
⁵ Division of Public Health, Hygiene and Epidemiology, Tohoku Medical Pharmaceutical University, 1-15-1 Fukumuro, Sendai 983-8536, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
⁶ Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1, Seiryomachi, Sendai 980-8574, Miyagi, Japan; Department of Maternal and Fetal Therapeutics, Tohoku University Graduate School of Medicine, 1-1, Seiryomachi, Sendai 980-8574, Miyagi, Japan.
⁷ Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, 1-1, Seiryomachi, Sendai 980-8574, Miyagi, Japan; Environment and Genome Research Center, Tohoku University Graduate School of Medicine, 2-1, Seiryomachi, Sendai 980-8575, Miyagi, Japan; Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan.
⁸ Division of Molecular Epidemiology, Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, 2-1, Seiryomachi, Sendai 980-8573, Miyagi, Japan; Division of Molecular Epidemiology, Tohoku University Graduate School of Medicine, 2-1, Seiryomachi, Sendai 980-8575, Miyagi, Japan; International Research Institute of Disaster Science, Tohoku University, 468-1, Aramaki, Sendai 980-8572, Miyagi, Japan.

PMID: 37992490
DOI: 10.1016/j.preghy.2023.11.002

Abstract

Objectives: This study aimed to investigate the association between maternal birth weight (MBW) and hypertensive disorders of pregnancy (HDP) according to the gestational age when HDP develops.

Study design: A total of 77,345 subjects were included in this prospective birth cohort study. The association between MBW and HDP was investigated by a multinomial logistic regression model.

Main outcome measures: Early-onset HDP (EO-HDP), preterm late-onset HDP (preterm LO-HDP), and term late-onset HDP (term LO-HDP).

Results: Lower MBW was associated with higher odds of preterm and term LO-HDP (p-values for trend < 0.0001 and = 0.0005, respectively). A linear association between MBW and EO-HDP was observed (p-values for trend = 0.0496). The shape of the association between MBW and preterm LO-HDP was a combination of the associations between MBW with EO-HDP or LO-HDP. The effect size of the association between MBW < 2,500 g and EO-HDP was lower than that of MBW < 2,500 g with preterm or term LO-HDP. The adjusted odds ratios for EO-HDP, preterm LO-HDP, and term LO-HDP in subjects with MBW < 2,500 g were 1.052 (95 % confidence interval [CI]: 0.665-1.664), 1.745 (95 % CI: 1.220-2.496), and 1.496 (95 % CI: 1.154-1.939), respectively.

Conclusions: MBW was associated with HDP, regardless of gestational age when HDP developed. Furthermore, the association of MBW < 2,500 g with preterm or term LO-HDP was stronger than that with EO-HDP.

Keywords: Birth weight; Hypertensive disorders of pregnancy.

MeSH terms

Birth Weight
Child
Cohort Studies
Female
Humans
Hypertension, Pregnancy-Induced* / epidemiology
Infant, Newborn
Japan / epidemiology
Pre-Eclampsia*
Pregnancy
Prospective Studies