Pyripyropene U, a new alkaloid from the sponge-derived fungus Aspergillus sp. SCSIO41420

Zhu Chen; Jianglian She; Juan Liu; Bo Peng; Zhimin Yuan; Xuefeng Zhou

doi:10.1080/14786419.2023.2284866

Pyripyropene U, a new alkaloid from the sponge-derived fungus Aspergillus sp. SCSIO41420

Nat Prod Res. 2023 Nov 22:1-6. doi: 10.1080/14786419.2023.2284866. Online ahead of print.

Authors

Zhu Chen¹, Jianglian She², Juan Liu², Bo Peng³, Zhimin Yuan⁴, Xuefeng Zhou²

Affiliations

¹ Guangdong Ocean Association, Guangzhou, China.
² CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
³ Institute for Environmental and Climate Research, Jinan University, Guangzhou, China.
⁴ Department of Nutrition, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou China.

PMID: 37990846
DOI: 10.1080/14786419.2023.2284866

Abstract

One new alkaloid, named pyripyropene U (1), and six known natural products (2-7) were obtained from the marine sponge-derived fungus Aspergillus sp. SCSIO41420. Their structures were determined by detailed nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses, while the absolute configurations of the new compound were unambiguously confirmed by theoretical electronic circular dichroism (ECD) calculation. Those natural products were evaluated in the antimicrobial tests against various fungi and bacteria, and 7 possessed obvious inhibitory activity against Staphylococcus aureus ATCC 29213.

Keywords: Aspergillus sp.; Sponge-derived fungus; antimicrobial activity; pyripyropene U.