Epithelial homeostasis: Cell size shapes cell fate

Xiang Teng; Yusuke Toyama

doi:10.1016/j.cub.2023.10.022

Epithelial homeostasis: Cell size shapes cell fate

Curr Biol. 2023 Nov 20;33(22):R1205-R1207. doi: 10.1016/j.cub.2023.10.022.

Authors

Xiang Teng¹, Yusuke Toyama²

Affiliations

¹ Mechanobiology Institute, National University of Singapore, Singapore.
² Mechanobiology Institute, National University of Singapore, Singapore; Department of Biological Sciences, National University of Singapore, Singapore. Electronic address: dbsty@nus.edu.sg.

PMID: 37989102
DOI: 10.1016/j.cub.2023.10.022

Abstract

A new study shows that cell size, in conjunction with specific signaling pathways, controls apoptosis within developing tissues. Cells with smaller sizes and relatively smaller sizes compared to their neighbors exhibit an increased likelihood of undergoing apoptosis. These processes are regulated by the Hippo/YAP and Notch pathways, respectively.

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MeSH terms

Cell Differentiation
Cell Proliferation
Cell Size
Homeostasis
Protein Serine-Threonine Kinases* / metabolism
Signal Transduction*

Substances

Protein Serine-Threonine Kinases