We identified highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b in wild birds, poultry, and a lion in Peru during November 2022-February 2023 and markers associated with transmission adaptation and antiviral drug resistance. Continuous genomic surveillance is needed to inform public health measures and avoid mass animal deaths.
Keywords: H5N1; HPAI; Peru; avian influenza; highly pathogenic avian influenza A(H5N1); influenza; mammals; poultry; respiratory infections; viruses; wild birds; zoonoses.