Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock

Nisha Hariharan; Alisha Kabadi; Michelle Don; Mazen Odish; Benjamin Heyman

doi:10.3390/hematolrep15040064

Composite Angioimmunoblastic T-Cell Lymphoma and Diffuse Large B-Cell Lymphoma Presenting with Distributive Shock

Hematol Rep. 2023 Nov 16;15(4):627-633. doi: 10.3390/hematolrep15040064.

Authors

Nisha Hariharan¹, Alisha Kabadi², Michelle Don³, Mazen Odish², Benjamin Heyman⁴

Affiliations

¹ Department of Medicine, Division of Hematology/Oncology, University of California, La Jolla, CA 92093, USA.
² Department of Medicine, Division of Pulmonary, Critical Care, Sleep Medicine, and Physiology, University of California, La Jolla, CA 92093, USA.
³ Department of Pathology, University of California, La Jolla, CA 92093, USA.
⁴ Department of Medicine, Division of Regenerative Medicine, University of California, La Jolla, CA 92093, USA.

Abstract

Diffuse large B-cell lymphoma (DLBCL) and angioimmunoblastic T-cell lymphoma (AITL) are two subtypes of non-Hodgkin lymphoma (NHL). The simultaneous occurrence of DLBCL and AITL in a composite lymphoma is very rare, and there are no established treatment regimens. We present the case of an 85-year-old male admitted to the intensive care unit with distributive shock, lymphocytosis, and lymphadenopathy, who was subsequently diagnosed with composite AITL and DLBCL, and treated with brentuximab vedotin (BV) and rituximab. To our knowledge, this is the first case of composite lymphoma presenting with distributive shock and treated with BV and rituximab, with successful resolution of shock.

Keywords: angioimmunoblastic T-cell lymphoma; brentuximab vedotin; composite lymphoma; diffuse large B-cell lymphoma; shock.

Publication types

Case Reports

Grants and funding

This research received no external funding.