The aberrant glycolysis in kidney proximal tubule: potential therapeutic target for DKD

Keizo Kanasaki

doi:10.1016/j.kint.2023.09.019

The aberrant glycolysis in kidney proximal tubule: potential therapeutic target for DKD

Kidney Int. 2023 Dec;104(6):1056-1059. doi: 10.1016/j.kint.2023.09.019.

Author

Keizo Kanasaki¹

Affiliation

¹ Department of Internal Medicine 1, Faculty of Medicine, Shimane University, Izumo, Japan. Electronic address: kkanasak@med.shimane-u.ac.jp.

PMID: 37981426
DOI: 10.1016/j.kint.2023.09.019

Abstract

The presence of glycolysis in kidney proximal tubule has been long debated. However, recent reports suggest that aberrant glycolysis is induced in pathologic conditions and may play a critical role in kidney damage. Azushima et al. provided additional evidence that the accumulation of glycolysis-derived lactate could be the clue to understanding the pathogenesis of diabetic kidney disease.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Glycolysis
Kidney Tubules*
Kidney Tubules, Proximal
Kidney*
Lactic Acid

Substances

Lactic Acid