In-situ integrated electrodes of FeM-MIL-88/CP for simultaneous ultra-sensitive detection of dopamine and acetaminophen based on crystal engineering strategy

Yue Wang; Dongmei Ren; Yan Zhang; Junguo Li; Wei Meng; Boran Tong; Jing Zhang; Chao Han; Lei Dai

doi:10.1016/j.aca.2023.341936

In-situ integrated electrodes of FeM-MIL-88/CP for simultaneous ultra-sensitive detection of dopamine and acetaminophen based on crystal engineering strategy

Anal Chim Acta. 2023 Dec 1:1283:341936. doi: 10.1016/j.aca.2023.341936. Epub 2023 Oct 19.

Authors

Yue Wang¹, Dongmei Ren¹, Yan Zhang², Junguo Li³, Wei Meng⁴, Boran Tong¹, Jing Zhang¹, Chao Han⁵, Lei Dai⁶

Affiliations

¹ College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063009, China.
² School of Environmental Science and Engineering, Tianjin University, Tianjin, 300350, China.
³ College of Metallurgy and Energy, North China University of Science and Technology, Tangshan, 063009, China.
⁴ College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063009, China. Electronic address: mengwei@ncst.edu.cn.
⁵ College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063009, China. Electronic address: hanchao@ncst.edu.cn.
⁶ College of Chemical Engineering, North China University of Science and Technology, Tangshan, 063009, China. Electronic address: dailei_b@163.com.

PMID: 37977775
DOI: 10.1016/j.aca.2023.341936

Abstract

Designing and exploiting integrated electrodes is the current inevitable trend to realize the sustainable development of electrochemical sensors. In this work, a series of integrated electrodes prepared by in situ growing the second metal ion-modulated FeM-MIL-88 (M = Mn, Co and Ni) on carbon paper (CP) (FeM-MIL-88/CP) were constructed as the electrochemical sensing platforms for the simultaneous detection of dopamine (DA) and acetaminophen (AC). Among them, FeMn-MIL-88/CP exhibited the best sensing behaviors and achieved the trace detection for DA and AC owing to synergistic catalysis between Fe³⁺, Mn²⁺ and CP. The electrochemical sensor based on FeMn-MIL-88/CP showed ultra-high sensitivities of 2.85 and 7.46 μA μM^-1 cm^-2 and extremely low detection limits of 0.082 and 0.015 μM for DA and AC, respectively. The FeMn-MIL-88/CP also exhibited outstanding anti-interference ability, repeatability and stability, and satisfactory results were also obtained in the detection of actual samples. The mechanism of Mn²⁺ modulation on the electrocatalytic activity of FeMn-MIL-88/CP towards DA and AC was revealed for the first time through the density functional theory (DFT) calculations. Good adsorption energy and rapid electron transfer worked synergistically to improve the sensing performances of DA and AC. This work not only provided a high-performance integrated electrode for the sensing field, but also demonstrated the influencing factors of electrochemical sensing at the molecular levels, laying a theoretical foundation for the sustainable development of subsequent electrochemical sensing.

Keywords: Acetaminophen; DFT; Dopamine; Electrochemical sensing; Fe-MIL-88.

MeSH terms

Acetaminophen*
Dopamine* / chemistry
Electrochemical Techniques / methods
Electrodes
Electron Transport
Limit of Detection

Substances

Dopamine
Acetaminophen