Connexins and blood-brain barrier: Beyond the gap

Audrey Chagnot; Axel Montagne

doi:10.1016/j.neuron.2023.10.032

Connexins and blood-brain barrier: Beyond the gap

Neuron. 2023 Nov 15;111(22):3499-3501. doi: 10.1016/j.neuron.2023.10.032.

Authors

Audrey Chagnot¹, Axel Montagne²

Affiliations

¹ UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK. Electronic address: audrey.chagnot@ed.ac.uk.
² UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK; Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK. Electronic address: axel.montagne@ed.ac.uk.

PMID: 37972562
DOI: 10.1016/j.neuron.2023.10.032

Abstract

In this issue of Neuron, Zhan, Meng, et al.¹ explore the non-canonical roles of connexin-43 in brain endothelial cells and connect its faltering expression to the depletion of nicotinamide adenine dinucleotide (NAD), mitochondrial stress, and blood-brain barrier rupture.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Blood-Brain Barrier* / metabolism
Brain / metabolism
Connexins* / metabolism
Endothelial Cells / metabolism
NAD / metabolism
Neurons / metabolism

Substances

Connexins
NAD

Grants and funding

MR/V032488/1/MRC_/Medical Research Council/United Kingdom