Combining ultrasound and microelectrode recordings for postoperative localization of subthalamic electrodes in Parkinson's disease

Abstract

Objective: To assess transcranial sonography (TCS) as stand-alone tool and in combination with microelectrode recordings (MER) as a method for the postoperative localization of deep brain stimulation (DBS) electrodes in the subthalamic nucleus (STN).

Methods: Individual dorsal and ventral boundaries of STN (n = 12) were determined on intraoperative MER. Postoperatively, a standardized TCS protocol was applied to measure medio-lateral, anterior-posterior and rostro-caudal electrode position using visualized reference structures (midline, substantia nigra). TCS and combined TCS-MER data were validated using fusion-imaging and clinical outcome data.

Results: Test-retest reliability of standard TCS measures of electrode position was excellent. Computed tomography and TCS measures of distance between distal electrode contact and midline agreed well (Pearson correlation; r = 0.86; p < 0.001). Comparing our "gold standard" of rostro-caudal electrode localization relative to STN boundaries, i.e. combining MRI-based stereotaxy and MER data, with the combination of TCS and MER data, the measures differed by 0.32 ± 0.87 (range, -1.35 to 1.25) mm. Combined TCS-MER data identified the clinically preferred electrode contacts for STN-DBS with high accuracy (Coheńs kappa, 0.86).

Conclusions: Combined TCS-MER data allow for exact localization of STN-DBS electrodes.

Significance: Our method provides a new option for monitoring of STN-DBS electrode location and guidance of DBS programming in Parkinson's disease.

Keywords: Deep brain stimulation; Neuroimaging; Parkinson’s disease; Stereotactic neurosurgery; Subthalamic nucleus; Transcranial ultrasound.