Social networks are an important factor in developing and maintaining social relationships. The social brain network comprises brain regions that differ in terms of their location, structure, and functioning, and these differences tend to vary among individuals with different social network sizes. However, it remains unknown how social cognitive abilities such as empathy can affect social network size. The goal of our study was to examine the relationship between brain regions in the social brain network, empathy, and individual social network size by using the Social Network Index, which measures social network diversity, size, and complexity by assessing 12 different types of relationships. We performed voxel-based morphometry and mediation analyses using data from questionnaires and structural magnetic resonance imaging data in a sample of 204 young adults. Our findings showed that the gray matter volume of the dorsomedial prefrontal cortex (dmPFC) was inversely associated with social network size and cognitive empathy mediated this association, suggesting that decreased gray matter volume in the dmPFC is associated with greater utilization of cognitive empathy, which, in turn, seems to increase social network size. A potential mechanism explaining this inverse relationship could be cognitive pruning, a phenomenon that occurs in the brain between early adolescence and adulthood, but future longitudinal studies are needed. In conclusion, our findings provide information about the neurocognitive mechanisms involved in the formation and maintenance of social networks.
Keywords: Cognitive pruning; Mediation analysis; Mentalizing; Neuroimaging; Social brain; Social network index.
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