Risks of Proton Pump Inhibitors in Patients with Cirrhosis: Please Peruse the Indications

Dig Dis Sci. 2024 Jan;69(1):7-9. doi: 10.1007/s10620-023-08153-3. Epub 2023 Nov 15.

Abstract

The use of proton pump inhibitor (PPI) in cirrhotic patients can be associated with increased risks of long-term mortality, decompensation, hepatic encephalopathy, spontaneous bacterial peritonitis, and infection, but not with short-term mortality. Ensure clear indications at lowest effective dose of is mandatory for the use of PPI among cirrhotic patients.

Keywords: Cirrhosis; Hepatic decompensation; Hepatocellular carcinoma; Proton pump inhibitors; Spontaneous bacterial peritonitis.

Publication types

  • Editorial

MeSH terms

  • Bacterial Infections* / complications
  • Bacterial Infections* / drug therapy
  • Hepatic Encephalopathy* / etiology
  • Humans
  • Liver Cirrhosis / complications
  • Liver Cirrhosis / drug therapy
  • Peritonitis* / microbiology
  • Proton Pump Inhibitors / adverse effects

Substances

  • Proton Pump Inhibitors