Engineered organoids for biomedical applications

Natan Roberto de Barros; Canran Wang; Surjendu Maity; Arne Peirsman; Rohollah Nasiri; Anna Herland; Menekse Ermis; Satoru Kawakita; Bruna Gregatti Carvalho; Negar Hosseinzadeh Kouchehbaghi; Rondinelli Donizetti Herculano; Zuzana Tirpáková; Seyed Mohammad Hossein Dabiri; Jean Lucas Tanaka; Natashya Falcone; Auveen Choroomi; RunRun Chen; Shuyi Huang; Elisheva Zisblatt; Yixuan Huang; Ahmad Rashad; Danial Khorsandi; Ankit Gangrade; Leon Voskanian; Yangzhi Zhu; Bingbing Li; Mohsen Akbari; Junmin Lee; Mehmet Remzi Dokmeci; Han-Jun Kim; Ali Khademhosseini

doi:10.1016/j.addr.2023.115142

Engineered organoids for biomedical applications

Adv Drug Deliv Rev. 2023 Dec:203:115142. doi: 10.1016/j.addr.2023.115142. Epub 2023 Nov 13.

Authors

Natan Roberto de Barros¹, Canran Wang², Surjendu Maity³, Arne Peirsman⁴, Rohollah Nasiri⁵, Anna Herland⁵, Menekse Ermis³, Satoru Kawakita³, Bruna Gregatti Carvalho⁶, Negar Hosseinzadeh Kouchehbaghi⁷, Rondinelli Donizetti Herculano⁸, Zuzana Tirpáková⁹, Seyed Mohammad Hossein Dabiri¹⁰, Jean Lucas Tanaka¹¹, Natashya Falcone³, Auveen Choroomi³, RunRun Chen¹², Shuyi Huang¹², Elisheva Zisblatt³, Yixuan Huang³, Ahmad Rashad³, Danial Khorsandi³, Ankit Gangrade³, Leon Voskanian³, Yangzhi Zhu³, Bingbing Li¹², Mohsen Akbari¹⁰, Junmin Lee¹³, Mehmet Remzi Dokmeci³, Han-Jun Kim¹⁴, Ali Khademhosseini¹⁵

Affiliations

¹ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA. Electronic address: nbarros@terasaki.org.
² Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA 91125, USA.
³ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA.
⁴ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Plastic and Reconstructive Surgery, Ghent University Hospital, Ghent, Belgium.
⁵ Division of Nanobiotechnology, Department of Protein Science, Science for Life Laboratory, KTH Royal Institute of Technology, 17165 Solna, Sweden.
⁶ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Department of Material and Bioprocess Engineering, School of Chemical Engineering, University of Campinas (UNICAMP), 13083-970 Campinas, Brazil.
⁷ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Department of Textile Engineering, Amirkabir University of Technology (Tehran Polytechnic), Hafez Avenue, 1591634311 Tehran, Iran.
⁸ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA; São Paulo State University (UNESP), Bioengineering and Biomaterials Group, School of Pharmaceutical Sciences, Araraquara, SP, Brazil.
⁹ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 04181 Kosice, Slovakia.
¹⁰ Laboratory for Innovations in Micro Engineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC V8P 5C2, Canada.
¹¹ Butantan Institute, Viral Biotechnology Laboratory, São Paulo, SP Brazil; University of São Paulo (USP), São Paulo, SP Brazil.
¹² Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; Autonomy Research Center for STEAHM (ARCS), California State University, Northridge, CA 91324, USA.
¹³ Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongbuk 37673, Republic of Korea.
¹⁴ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA; College of Pharmacy, Korea University, Sejong 30019, Republic of Korea. Electronic address: hanjun@korea.ac.kr.
¹⁵ Terasaki Institute for Biomedical Innovation (TIBI), Los Angeles, CA 90064, USA. Electronic address: khademh@terasaki.org.

PMID: 37967768
PMCID: PMC10842104 (available on 2024-12-01)
DOI: 10.1016/j.addr.2023.115142

Abstract

As miniaturized and simplified stem cell-derived 3D organ-like structures, organoids are rapidly emerging as powerful tools for biomedical applications. With their potential for personalized therapeutic interventions and high-throughput drug screening, organoids have gained significant attention recently. In this review, we discuss the latest developments in engineering organoids and using materials engineering, biochemical modifications, and advanced manufacturing technologies to improve organoid culture and replicate vital anatomical structures and functions of human tissues. We then explore the diverse biomedical applications of organoids, including drug development and disease modeling, and highlight the tools and analytical techniques used to investigate organoids and their microenvironments. We also examine the latest clinical trials and patents related to organoids that show promise for future clinical translation. Finally, we discuss the challenges and future perspectives of using organoids to advance biomedical research and potentially transform personalized medicine.

Keywords: Disease modeling; Organoids; Regenerative medicine; Spheroids; Stem cell; Therapies.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Biomedical Research* / methods
Drug Development
Humans
Organoids*
Precision Medicine / methods
Stem Cells

Abstract

Publication types

MeSH terms

Grants and funding