Antibiotic resistance among pathogenic bacteria is one of the most severe global challenges. It is predicted that over ten million lives will be lost annually by 2050. Phage therapy is a promising alternative to antibiotics. However, the ease of development of phage resistance during therapy is a concern. This review focuses on the possible ways to overcome phage resistance in phage therapy.
Keywords: Phage; Phage engineering; Phage resistance; Phage therapy; Phage training; bacteria coevolution.
© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.