Compartment-specific protein interactions in beryllium lung disease

Li Li; Brian Vestal; Margaret M Mroz; Sucai Liu; Kristyn MacPhail; Tim J Griffin; Ivana V Yang; Lisa A Maier; Maneesh Bhargava

doi:10.1183/23120541.00138-2023

Compartment-specific protein interactions in beryllium lung disease

ERJ Open Res. 2023 Nov 13;9(6):00138-2023. doi: 10.1183/23120541.00138-2023. eCollection 2023 Nov.

Authors

Li Li^{1

2}, Brian Vestal^{3

4}, Margaret M Mroz¹, Sucai Liu¹, Kristyn MacPhail¹, Tim J Griffin⁵, Ivana V Yang^{2

6

7}, Lisa A Maier^{1

2

8}, Maneesh Bhargava⁹

Affiliations

¹ Division of Environmental and Occupational Health Sciences, Department of Medicine, National Jewish Health, Denver, CO, USA.
² Division of Pulmonary and Critical Care Sciences, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
³ Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
⁴ Department of Biostatistics and Bioinformatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁵ Department of Biochemistry, Molecular Biology, and Biophysics, Center for Mass Spectrometry and Proteomics, University of Minnesota, Minneapolis, MN, USA.
⁶ Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁷ Department of Epidemiology, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁸ Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
⁹ Pulmonary, Allergy, Critical Care and Sleep, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.

Abstract

The study provides insights into proteins that may be relevant in BeS and CBD. It provides a framework to investigate the global changes in lung compartment-specific inflammatory cells to better understand the potential interplay of proteins in CBD. https://bit.ly/3PLNTXC.

Abstract

Grants and funding