Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis

Zihao Liu; Yaqi Du; Shendan Xu; Minting Li; Xuemei Lu; Guangjie Tian; Jing Ye; Bo Zhao; Pengfei Wei; Yonglan Wang

doi:10.1016/j.isci.2023.108212

Histatin 1-modified SIS hydrogels enhance the sealing of peri-implant mucosa to prevent peri-implantitis

iScience. 2023 Oct 14;26(11):108212. doi: 10.1016/j.isci.2023.108212. eCollection 2023 Nov 17.

Authors

Zihao Liu¹, Yaqi Du², Shendan Xu², Minting Li², Xuemei Lu², Guangjie Tian², Jing Ye³, Bo Zhao⁴, Pengfei Wei⁴, Yonglan Wang²

Affiliations

¹ Zhongnuo Dental Hospital, Tianjin Nankai District, Tianjin 300101, China.
² School and Hospital of Stomatology, Tianjin Medical University, Tianjin 30070, China.
³ Department of Stomatology, Tianjin Hospital, Tianjin 300211, China.
⁴ Beijing Biosis Healing Biological Technology Co., Ltd., Beijing 102600, China.

Abstract

Dental implants make it possible to replace teeth in more sophisticated ways. Nevertheless, peri-implantitis is one of the leading causes of implant failure, which can be avoided with proper soft tissue sealing. The aim of this study was to achieve the promotion of the synthesis of peri-implant epithelial hemidesmosome through Histatin 1 and porcine small intestinal submucosa (SIS) hydrogel to form a good peri-implant seal. The results show that hydrogel can improve the biological barrier function around implants by combining antibacterial, promoting soft tissue healing and promoting epithelial bonding. This means that the morphology and anti-infection ability of soft tissue are enhanced, which ensures the long-term stability of the implant.SIS-Hst1 hydrogel has certain clinical application in the prevention and early treatment of peri-implantitis. In conclusion, Hst1-SIS hydrogel, as a local administration system, provides experimental evidence for the prevention of peri-implant disease.

Keywords: Biomaterials; Dentistry.