Abstract
Increasing concentrations of malonaldehyde and beta-propiolactone were increasingly mutagenic with 7 mutants of Salmonella typhimurium, 5 of which mutated bya frameshift mechanism and 2 of which mutated through base-pair substitution. The antioxidants vitamin C, vitamin E, selenium and butylated hydroxytoluene (BHT) at 3 logarithmic concentrations markedly reduced mutagenesis in those strains which mutated by frameshift mechanism.
MeSH terms
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Ascorbic Acid / pharmacology
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Butylated Hydroxytoluene / pharmacology
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Dose-Response Relationship, Drug
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Drug Evaluation, Preclinical
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Genetic Techniques
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Lactones / pharmacology*
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Malonates / pharmacology*
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Malondialdehyde / pharmacology*
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Mutagens* / antagonists & inhibitors
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Propiolactone / pharmacology*
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Salmonella typhimurium / genetics
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Selenium / pharmacology
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Vitamin E / pharmacology
Substances
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Lactones
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Malonates
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Mutagens
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Vitamin E
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Butylated Hydroxytoluene
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Malondialdehyde
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Propiolactone
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Selenium
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Ascorbic Acid