The Role of Vasodilator-stimulated Phosphoproteins in the Development of Malignant Tumors

Jiandong Gui; Hangsheng Zhou; Hongyuan Wan; Dongjie Yang; Qing Liu; Lijie Zhu; Yuanyuan Mi

doi:10.2174/0115680096262439231023110106

The Role of Vasodilator-stimulated Phosphoproteins in the Development of Malignant Tumors

Curr Cancer Drug Targets. 2023 Nov 14. doi: 10.2174/0115680096262439231023110106. Online ahead of print.

Authors

Jiandong Gui^{1

2}, Hangsheng Zhou^{1

2}, Hongyuan Wan^{1

2}, Dongjie Yang², Qing Liu^{2

3}, Lijie Zhu², Yuanyuan Mi²

Affiliations

¹ Wuxi School of Medicine, Jiangnan University, 1800 Lihudadao, Wuxi 214122, Jiangsu Province, China.
² Department of Urology, Affiliated Hospital of Jiangnan University, 1000 Hefeng Road, Wuxi 214122, Jiangsu Province, China.
³ Huadong Sanatorium, 67 Dajishan, Wuxi 214122, Jiangsu Province, China.

PMID: 37962042
DOI: 10.2174/0115680096262439231023110106

Abstract

Vasodilator-stimulated phosphoprotein (VASP) is an actin-binding protein that includes three structural domains: Enabled/VASP homolog1 (EVH1), EVH2, and proline-rich (PRR). VASP plays an important role in various cellular behaviors related to cytoskeletal regulation. More importantly, VASP plays a key role in the progression of several malignant tumors and is associated with malignant cell proliferation, invasion, and metastasis. Here, we have summarized current studies on the impact of VASP on the development of several malignant tumors and their mechanisms. This study provides a new theoretical basis for clinical molecular diagnosis and molecular targeted therapy.

Keywords: biomarker; function; invasion; malignant tumors; metastasis; vasodilator-stimulated phosphoprotein.