Review of T cell proliferation regulatory factors in treatment and prognostic prediction for solid tumors

Jiayu Li; Shuhan Ma; Hongdi Pei; Jici Jiang; Quan Zou; Zhibin Lv

doi:10.1016/j.heliyon.2023.e21329

Review of T cell proliferation regulatory factors in treatment and prognostic prediction for solid tumors

Heliyon. 2023 Oct 29;9(11):e21329. doi: 10.1016/j.heliyon.2023.e21329. eCollection 2023 Nov.

Authors

Jiayu Li^{1

2}, Shuhan Ma¹, Hongdi Pei¹, Jici Jiang¹, Quan Zou^{3

4}, Zhibin Lv¹

Affiliations

¹ Student Innovation Competition Team, College of Biomedical Engineering, Sichuan University, Chengdu 610065, China.
² College of Life Science, Sichuan University, Chengdu 610065, China.
³ Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China, Chengdu 610054, China.
⁴ Yangtze Delta Region Institute (Quzhou), University of Electronic Science and Technology of China, Quzhou 324000, China.

Abstract

T cell proliferation regulators (Tcprs), which are positive regulators that promote T cell function, have made great contributions to the development of therapies to improve T cell function. CAR (chimeric antigen receptor) -T cell therapy, a type of adoptive cell transfer therapy that targets tumor cells and enhances immune lethality, has led to significant progress in the treatment of hematologic tumors. However, the applications of CAR-T in solid tumor treatment remain limited. Therefore, in this review, we focus on the development of Tcprs for solid tumor therapy and prognostic prediction. We summarize potential strategies for targeting different Tcprs to enhance T cell proliferation and activation and inhibition of cancer progression, thereby improving the antitumor activity and persistence of CAR-T. In summary, we propose means of enhancing CAR-T cells by expressing different Tcprs, which may lead to the development of a new generation of cell therapies.

Keywords: CAR-T; Cancer prognosis prediction; Immunocyte therapy; Solid tumor; T cell proliferation and activation; T cell proliferation regulators.

Publication types

Review